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Introduction: CF is an inherited disease in which exocrine glands produce abnormally viscous mucus, causing chronic respiratory and digestive dysfunctions. Recurrent infections by Ps. aeruginosa and others are associated with a faster deterioration in lung function and increase morbidity and mortality. Inhaled Tobramycin and mucolytic therapy with Alpha-Dornase have improved lung function and decreased hospitalization days. In Uruguay, access to these drugs was restricted because it wasn't covered until December 2007. A system of universal coverage, under a policy framework based in the best evidence and supported by a strong monitoring program was implemented. The criteria for treatment with Tobramycin and Alpha-Dornase are shown in table 1. A systematic process of evaluation was established since the beginning of the coverage.

La utilización de cada artículo de uso médico representa un riesgo de infección hospitalaria u otros eventos adversos, si no han sido debidamente procesados. La ocurrencia de brotes hospitalarios, relacionados a fallidos procesos de desinfección o esterilización, ha sido ampliamente documentada. Los procesos no solo dependen de las tecnologías disponibles sino también de la utilización por parte del personal de la salud, de protocolos acordes a la evidencia científica, con acciones consensuadas y en pro de obtener los mejores resultados.